Endocrine Abstracts

Using real-time PCR, we found that RDH12 is highly expressed in the skin of Macacafascicularis (mf). It has been known that RDH12 is a retinol dehydrogenase that catalyzes the reduction of retinal into retinol and play an important role in the visual cycle. Indeed, its deficiency is the cause of Leber’s congenital amaurosis 3, a genetic disorder characterized by retinal dystrophy affecting both rods and cones. Previously, we have shown that many of the members of the reti...